Shuman Lab

Columbia University

PI: Howard Shuman
Microbiology
212-305-1482



Interests

microbiology, Legionella, small RNA, pathogenesis, gene regulation, regulatory pathways, LCV, Type IV secretion, Bacteria, Intracellular Trafficking Pathways, cancer research

Systems and Approaches

Legionella genetics, genetic, Microarray, bacterial genetics, global gene regulation, protein purification, Infections, Molecular Microbiology, bacterial pathogenesis, Microbial Pathogenesis, microarrays, northern blots

Research Summary

We study the biology of Legionella pneumophila and its interaction with protist and mammalian host cells. Shown above is an image of GFP-expressing Legionella growing inside 4 replicative vacuoles in the soil amoeba, Dictyostelium discoideum (image courtesy of Chris Pericone)

Publications

SigmaS controls multiple pathways associated with intracellular multiplication of Legionella pneumophila.

Journal of bacteriology 191(8):2461-73, 2009 Apr.
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Loss of RNase R induces competence development in Legionella pneumophila.

Journal of bacteriology, 2008 Oct 10.
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Legionella eukaryotic-like type IV substrates interfere with organelle trafficking.

PLoS pathogens 4(8), 2008.
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Host cell-dependent secretion and translocation of the LepA and LepB effectors of Legionella pneumophila.

Cellular microbiology 9(7):1660-71, 2007 Jul.
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Pathogen effector protein screening in yeast identifies Legionella factors that interfere with membrane trafficking.

Proceedings of the National Academy of Sciences of the United States of America 102(13):4866, 2005 Mar 29.
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The genomic sequence of the accidental pathogen Legionella pneumophila.

Science (New York, N.Y.) 305(5692):1966-8, 2004 Sep 24.
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The Legionella pneumophila icm locus: a set of genes required for intracellular multiplication in human macrophages.

Molecular microbiology 14(4):797-808, 1994 Nov.
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The art and design of genetic screens: Escherichia coli.

Nature reviews. Genetics 4(6):419-31, 2003 Jun.
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People

Howard Shuman
Columbia University
Professor
Shuman Lab
Legionella genetics
microbiology
Xavier Charpentier
Columbia University
Postdoc
Shuman Lab
genetic
Legionella
Sebastien P Faucher
Columbia University
Postdoc
Shuman Lab
Microarray
small RNA
Galadriel Astra Hovel-Miner
Columbia University
PhD Student
Shuman Lab
bacterial genetics, global gene regulation
pathogenesis, gene regulation, regulatory pathways
Moraima Irizarry
Columbia University
Research Assistant
Shuman Lab
protein purification
microbiology
Irina S Franco
Columbia University
Postdoc
Shuman Lab
Catherine A Mueller
Columbia University
Postdoc
Shuman Lab
Infections, Protein Purification
LCV, Type IV secretion
Assaf Levi
Columbia University
Postdoc
Shuman Lab
Molecular Microbiology
Joelle E Gabay
Columbia University
Research Associate
Shuman Lab
bacterial pathogenesis
Robert Glover
Columbia University
Postdoc
Shuman Lab
Microbial Pathogenesis
Bacteria, Intracellular Trafficking Pathways
Jessica Gross
Yeshiva University
Undergraduate
Shuman Lab
Janet Sum
Columbia University
Masters Student
Shuman Lab
microarrays, northern blots
microbiology, cancer research